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Dynamics and physiopathology of neuronal networks - UMR_S 667

INSERM unit 667 investigates the dynamic of interactions between the cerebral cortex and the basal ganglia. The basal ganglia comprise a group of subcortical nuclei (striatum, pallidum, subthalamic nucleus and substantia nigra) interconnected with the cerebral cortex via plurisynaptic neuronal circuits. The basal ganglia integrate information form the whole cerebral cortex and structures of the limbic system. In turn it influences areas of the cortical frontal lobe and defined premotor brainstem nuclei. Classically considered as part of the motor system, the basal ganglia are implicated in learning and maintenance of behavioral rules in relation to the environmental context and reinforcement history.

Dysfunction of the basal ganglia causes motor and cognitive impairments. Parkinson’s disease, Huntington’s chorea, hemiballismus result from impairment of the neuronal circuits connecting the basal ganglia to motor cortical areas. Obsessive compulsive disorders, shizophrenia, drug addiction involve the basal ganglia circuits related to prefrontal areas and limbic system. In addition, through their reciprocal connections with the thalamus and the cerebral cortex the basal ganglia contribute to the control and propagation of paroxysmal rhythmic discharges in some epilepsies such as the epilepsy absence.

The organization and functional properties of these neural networks are analyzed in normal and in animal models of human pathologies Studies are performed from cellular level to integrated systems using anatomical, electrophysiological and neurochemical approaches.

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Contact Informations
Contact Informations
DENIAU Jean-Michel 
01 44 27 12 48
Physical address
11, Place Marcelin Berthelot 75231 Paris cedex 05

Laboratory's mail
Mailing address

Communications Contact
LEVI Marie-Hélène 
01 44 27 12 30
Administrative Contact


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