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Neurobiology of adaptive processes - UMR 7102

The general research interests of the Unit concern adaptive processes of the nervous system, during development, in the adult, and during aging. These processes are studied at two levels of organisation: 1) the molecular and cellular level, concerning ion channels, ionotropic and metabotropic synaptic receptors, second messengers and signal transduction pathways (cAMP, ceramide, kinases…) leading to regulation of gene expression; 2) a more integrated level of neuronal networks where these molecular signals are used; this includes behavioural analysis.

These studies concern in particular:
1) elementary mechanisms of information integration at the synapse and their relationship with neuronal excitability, either normal or pathological (e.g. epilepsy), in certain neural networks
2) Mechanisms of axon outgrowth, guidance, and synaptogenesis during normal development or during post-lesion reparation.
3) Neuronal stress and neuronal/glial death, both normal and pathological (ischemia, neurodegenerative diseases), and possible strategies of protection.
4) Cellular processes such as long-term synaptic plasticity (depression or facilitation), and the action of neurotransmitters as bases of learning et memory, but also of drug dependence.
The perspectives for these themes include a better understanding of certain integrated physiological processes (motor synchronisation, motor learning, memory…) as well as possible cellular bases of several pathological situations.
The integrative nature of this approach requires the use of multiple techniques, ranging from molecular biology and electrophysiology to behaviour. An important methodological characteristic is the almost systematic use of genetic mouse models (spontaneous mutants and transgenics); detailed post-genomic analysis of these animals allows a better understanding of the function(s) of these genes in adaptive neuronal processes. 

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Teams and research themes

Research Teams

  • Neuronal Death and Differentiation - B. Brugg
  • Neuronal and Glial Differentiation - I. Dusart
  • Développement Neuronal et Synaptogenèse - A. Lohof/R. Sharrard
  • Development and Plasticity of Neural Networks - A. Trembleau
  • Development and Ageing of the Nervous System - J. Mariani
  • Epistémologie des Neurosciences - J.G. Barbara
  • Navigation, Memory, Ageing - L. Rondi-Reig
  • Cellular Integration of Neuromodulatory Processes - P. Vincent
  • Adaptive NeuroComputation - A. Arleo
  • Neurophysiology and Behaviors - P. Faure
  • Cortical Network and Neurovascular Coupling - B. Lambolez/B. Cauli
  • Neuronal Networks and Physiopathological Rhythms - N. Leresche / R. Lambert 
Main publications

NPA member's publications : 2009

1- Brami-Cherrier K Roze E Girault JA Betuing S Caboche J  (2009) : Role of the ERK/MSK1 signaling pathway in chromatin remodelling and brain responses to drugs of abuse. J Neurochem. 2009 Jan 12.  [Abstract]  

2- Gautheron V Auffret A Mattson MP Mariani J Garabedian BV  (2009) : A new and simple approach for genotyping Alzheimer's disease presenilin-1 mutant knockin mice. J Neurosci Methods. 2009 May 21.  [Abstract]  

3- Igloi K Zaoui M Berthoz A Rondi-Reig L  (2009) : Sequential egocentric strategy is acquired as early as allocentric strategy: Parallel acquisition of these two navigation strategies. Hippocampus. 2009 Apr 9.  [Abstract]  

4- Janmaat S Frederic F Sjollema K Luiten P Mariani J van der Want J  (2009) : Formation and maturation of parallel fiber-purkinje cell synapses in the staggerer cerebellum ex vivo. J Comp Neurol.;512(4):467-77.  [Abstract]  

5- Karagiannis A Gallopin T David C Battaglia D Geoffroy H Rossier J Hillman EM Staiger JF Cauli B  (2009) : Classification of NPY-expressing neocortical interneurons. J Neurosci.;29(11):3642-59.  [Abstract]  

6- Kolomiets B Marzo A Caboche J Vanhoutte P Otani S  (2009) : Background Dopamine Concentration Dependently Facilitates Long-term Potentiation in Rat Prefrontal Cortex through Postsynaptic Activation of Extracellular Signal-Regulated Kinases. Cereb Cortex. 2009 Mar 12.  [Abstract]  

7- Laffaire J Rivals I Dauphinot L Pasteau F Wehrle R Larrat B Vitalis T Moldrich RX Rossier J Sinkus R Herault Y Dusart I Potier MC  (2009) : Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome. BMC Genomics.;10(1):138.  [Abstract]  

8- Sherrard RM Dixon KJ Bakouche J Rodger J Lemaigre-Dubreuil Y Mariani J  (2009) : Differential expression of TrkB isoforms switches climbing fiber-Purkinje cell synaptogenesis to selective synapse elimination. Dev Neurobiol. 2009 Jun 23.  [Abstract]  

9- Sotelo C Dusart I  (2009) : Intrinsic versus extrinsic determinants during the development of Purkinje cell dendrites. Neuroscience. 2009 Jan 1.  [Abstract]  

10- Spassky N Caille I  (2009) : [Pinwheel architecture of neural stem cell niche, the third dimension.] Med Sci (Paris).;25(1):17-18.  [Abstract]  

11- Trembleau A  (2009) : [Axonal mRNAs: from histochemical visualization to functional analyses.] J Soc Biol.;203(1):65-73. Epub 2009 Apr 10.  [Abstract]  

12- Trifilieff P Lavaur J Pascoli V Kappes V Brami-Cherrier K Pages C Micheau J Caboche J Vanhoutte P  (2009) : Endocytosis controls glutamate-induced nuclear accumulation of ERK. Mol Cell Neurosci.;41(3):325-36. Epub 2009 May 3.  [Abstract]  

13- Watson J Guzzetti S Franchi C Di Clemente A Burbassi S Emri Z Leresche N Parri HR Crunelli V Cervo L  (2009) : Gamma-hydroxybutyrate does not maintain self-administration but induces conditioned place preference when injected in the ventral tegmental area. Int J Neuropsychopharmacol. 2009 Jul 2:1-11.  [Abstract]  

14- Zanjani HS McFarland R Cavelier P Blokhin A Gautheron V Levenes C Bambrick LL Mariani J Vogel MW  (2009) : Death and survival of heterozygous Lurcher Purkinje cells In vitro. Dev Neurobiol. 2009 Mar 17.  [Abstract] 

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