Séminaire CulturChem | José Ruiz "Novel Ir(III) complexes: applications for photodynamic therapy cancer"

José Ruiz (Universidad de Murcia, Spain)
présentera un séminaire dans le cadre des conférences CulturChem

intitulé
"Novel Ir(III) complexes: applications for photodynamic therapy cancer"

Abstract. Photodynamic therapy (PDT) is a non-invasive antitumor approach that uses visible light to activate a prodrug, over a flexible time in a precise space,
destroying local tumor cells due to the generation of toxic singlet oxygen and/or reactive oxygen species (ROS).1 One of the setbacks of this technique is the low concentration of oxygen present in tumors.2 Interestingly, PDT can exhibit immunomodulatory functions in addition its direct tumor-destroying capability and provides an important opportunity to target CSCs selectively.3 Over the last years, our research group focused its attention on the development of precious metal complexes as (photo)therapeutic agents against cancer.4-5 During this talk, we will present our latest results on these topics.

1] A. Zamora, G. Vigueras, V.Rodríguez, M. D. Santana and J. Ruiz Coord. Chem. Rev., 2018, 360, 34-76.
[2] F. J. Ballester, E. Ortega, D. Bautista, M. D. Santana and J. Ruiz Chem. Commun., 2020, 56, 10301-10304.
[3] G. Vigueras, L. Markova, V. Novohradsky, A. Marco, N. Cutillas, H. Kostrhunova, J. Kasparkova, J. Ruiz and V. Brabec Inorg. Chem. Front., 2021, 8, 4696–4711.
[4] E. Ortega, C. Pérez-Arnaiz, V. Rodríguez, C. Janiak, N. Busto, B. García and J. Ruiz. Eur. J. Med. Chem., 2021, 222, 113600.
[5] J. Pracharova, G. Vigueras, V. Novohradsky, N. Cutillas, C. Janiak, H. Kostrhunova, J. Kasparkova, J. Ruiz and V. Brabec Chem. Eur. J., 2018. 24, 4607-4619.