• Santé

Dynamique de l'information génétique | DIG CANCER

  • Unité mixte de recherche

Publié le 27/04/2020 - Mis à jour le 13/12/2024

Équipes

Direction

  • Antonin Morillon

Direction adjointe

  • Valérie Borde

Autres tutelles

  • Centre National de la Recherche Scientifique | CNRS
  • Sorbonne Université

Publications sur HAL - Archive ouverte

Toutes les publications sur HAL
  • Article dans une revue

DNA damage-induced EMT controlled by the PARP dependent chromatin remodeler ALC1 promotes DNA repair efficiency through RAD51 in tumor cells

Fatemeh Rajabi, Rebecca Smith, Win-Yan Liu-Bordes, Michael Schertzer, Sebastien Huet, Arturo Londoño-Vallejo

Epithelial-to-mesenchymal transition (EMT) allows cancer cells to metastasize while acquiring resistance to apoptosis and chemotherapeutic agents with significant implications for patients’ prognosis and survival. Despite its clinical relevance, the mechanisms initiating EMT during cancer…

Molecular Biology of the Cell, 2024, 35 (12), pp.ar151. ⟨10.1091/mbc.E24-08-0370⟩. ⟨hal-04772296⟩

  • Article dans une revue

Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

Anne Fajac, Iva Simeonova, Julia Leemput, Marc Gabriel, Aurélie Morin, Vincent Lejour, Annaïg Hamon, Jeanne Rakotopare, Wilhelm Vaysse-Zinkhöfer, Eliana Eldawra, Marina Pinskaya, Antonin Morillon, Jean-Christophe Bourdon, Boris Bardot, Franck Toledo

The Trp53 gene encodes several isoforms of elusive biological significance. Here, we show that mice lacking the Trp53 alternatively spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpectedly lost a male-specific protection against Myc-…

eLife, 2024, 13, ⟨10.7554/eLife.92774⟩. ⟨hal-04717438⟩

  • Article dans une revue

Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeast Lachancea kluyveri

Sylvain Legrand, Asma Saifudeen, Hélène Bordelet, Julien Vernerey, Arnaud Guille, Amaury Bignaud, Agnès Thierry, Laurent Acquaviva, Maxime Gaudin, Aurore Sanchez, Dominic Johnson, Anne Friedrich, Joseph Schacherer, Matthew Neale, Valérie Borde, Romain Koszul, Bertrand Llorente

Meiotic recombination shows broad variations across species and along chromosomes and is often suppressed at and around genomic regions determining sexual compatibility such as mating type loci in fungi. Here, we show that the absence of Spo11-DSBs and meiotic recombination on Lakl0C-left, the…

Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (12), pp.e2312820121. ⟨10.1073/pnas.2312820121⟩. ⟨pasteur-04603593⟩

  • Article dans une revue

DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks

Lia M Pinto, Alexandros Pailas, Max Bondarchenko, Abhishek Bharadwaj Sharma, Katrin Neumann, Anthony J Rizzo, Céline Jeanty, Nathalie Nicot, Carine Racca, Mindy K Graham, Catherine Naughton, Yaqun Liu, Chun-Long Chen, Paul J Meakin, Nick Gilbert, Sébastien Britton, Alan K Meeker, Christopher M Heaphy, Florence Larminat, Eric Van dyck

Maintaining chromatin integrity at the repetitive non-coding DNA sequences underlying centromeres is crucial to prevent replicative stress, DNA breaks and genomic instability. The concerted action of transcriptional repressors, chromatin remodelling complexes and epigenetic factors controls…

Nucleic Acids Research, 2024, 52, pp.1136 - 1155. ⟨10.1093/nar/gkad1141⟩. ⟨hal-04716990⟩

Toutes les publications sur HAL

Coordonnées

Adresse postale

Dynamique de l'Information Génétique - DIG CANCER, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
Adresse physique
Dynamique de l'Information Génétique - DIG CANCER
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05
France
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