Dynamique de l'information génétique | DIG CANCER

• Article dans une revue

Pervasive formation of double-stranded RNAs by overlapping sense/antisense transcripts in budding yeast mitosis and meiosis

Ugo Szachnowski, Emmanuelle Becker, Igor Stuparevic, Maxime Wery, Olivier Sallou, Matéo Boudet, Anthony Bretaudeau, Antonin Morillon, Michael Primig

Previous RNA profiling studies revealed co-expression of overlapping sense/antisense (s/a) transcripts in pro- and eukaryotic organisms. Functional analyses in yeast have shown that certain s/a mRNA/mRNA and mRNA/lncRNA pairs form stable double-stranded RNAs (dsRNAs) that affect transcript…

RNA, 2025, pp.rna.080290.124. ⟨10.1261/rna.080290.124⟩. ⟨hal-04935733⟩

• Article dans une revue

Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression

Joseph M Josephides, Chun-Long Chen

Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learningbased tool that allows disentangling scRT profiles from heterogenous samples. We use single-cell copy number data to accurately perform missing…

Nature Communications, 2025, 16, ⟨10.1038/s41467-025-56783-0⟩. ⟨hal-05020639⟩

• Article dans une revue

Editorial: Epigenetic regulation of genome integrity and its implications in human diseases

Zhiming Li, Xiao Chen, Chun-Long Chen

Frontiers in Cell and Developmental Biology, 2024, 12, ⟨10.3389/fcell.2024.1535839⟩. ⟨hal-05020622⟩

• Article dans une revue

DNA damage-induced EMT controlled by the PARP dependent chromatin remodeler ALC1 promotes DNA repair efficiency through RAD51 in tumor cells

Fatemeh Rajabi, Rebecca Smith, Win-Yan Liu-Bordes, Michael Schertzer, Sebastien Huet, Arturo Londoño-Vallejo

Epithelial-to-mesenchymal transition (EMT) allows cancer cells to metastasize while acquiring resistance to apoptosis and chemotherapeutic agents with significant implications for patients’ prognosis and survival. Despite its clinical relevance, the mechanisms initiating EMT during cancer…

Molecular Biology of the Cell, 2024, 35 (12), pp.ar151. ⟨10.1091/mbc.E24-08-0370⟩. ⟨hal-04772296⟩