• Santé

Dynamique du noyau | DN

  • Unité mixte de recherche

Publié le 27/04/2020 - Mis à jour le 13/12/2024

Équipes

Direction

  • Angela Taddei

Direction adjointe

  • Nathalie Dostatni

Publications sur HAL - Archive ouverte

Toutes les publications sur HAL
  • Article dans une revue

Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis

Camille Landragin, Melissa Saichi, Marthe Laisné, Adeline Durand, Pacôme Prompsy, Renaud Leclere, Jérémy Mesple, Kyra Borgman, Amandine Trouchet, Marisa M Faraldo, Aurélie Chiche, Anne Vincent-Salomon, Hélène Salmon, Céline Vallot

<div><p>In breast cancer related to the BRCA1 mutation, luminal progenitor cells are believed to be the cells of origin, yet how these cells transform into invasive cancer cells remain poorly understood. Here, we combine single-cell epigenomic and transcriptomic data to reconstitute…

Molecular Cancer, 2025, 24 (1), pp.127. ⟨10.1186/s12943-025-02331-9⟩. ⟨inserm-05151042⟩

  • Article dans une revue

Parasitic plasmids are anchored to inactive regions of eukaryotic chromosomes through a nucleosome signal, Les plasmides parasites sont ancrés aux régions inactives des chromosomes eucaryotes par l'intermédiaire d'un signal nucléosomique.

Fabien Girard, Antoine Even, Agnès Thierry, Myriam Ruault, Léa Meneu, Pauline Larrous, Mickaël Garnier, Sandrine Adiba, Angela Taddei, Romain Koszul, Axel Cournac

Natural plasmids are common in prokaryotes, but few have been documented in eukaryotes. The natural 2µ plasmid present in the yeast Saccharomyces cerevisiae is one of these best-characterized exceptions. This highly stable genetic element has coexisted with its host for millions of years,…

EMBO Journal, 2025, 44 (7), pp.2134 - 2156. ⟨10.1038/s44318-025-00389-1⟩. ⟨hal-05121404⟩

  • Article dans une revue

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

Léa Meneu, Christophe Chapard, Jacques Serizay, Alex Westbrook, Etienne Routhier, Myriam Ruault, Manon Perrot, Alexandros Minakakis, Fabien Girard, Amaury Bignaud, Antoine Even, Géraldine Gourgues, Domenico Libri, Carole Lartigue, Aurèle Piazza, Agnès Thierry, Angela Taddei, Frédéric Beckouët, Julien Mozziconacci, Romain Koszul

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in the absence of coevolution. Using bacterial genomes integrated…

Science, 2025, 387 (6734), pp.eadm9466. ⟨10.1126/science.adm9466⟩. ⟨hal-04937691⟩

  • Article dans une revue

Interphase chromatin biophysics and mechanics: new perspectives and open questions

Antoine Coulon

The physical organization and properties of chromatin within the interphase nucleus are intimately linked to a wide range of functional DNA-based processes. In this context, interphase chromatin mechanics—that is, how chromatin, physically, responds to forces—is gaining increasing attention. Recent…

Current Opinion in Genetics and Development, 2025, 90, pp.102296. ⟨10.1016/j.gde.2024.102296⟩. ⟨hal-05015142⟩

Toutes les publications sur HAL

Contact details

Adresse postale

Dynamique du noyau, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
Adresse physique
Dynamique du noyau
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05 France
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