Dynamique du noyau | DN

• Pré-publication, Document de travail

Nuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus

Maxime Chazal, Aïssatou Aïcha Sow, Elodie Le Seac’h, Dana Hawasheen, Margarida Bonifacio, Mikael Feracci, Ségolène Gracias, Adrià Sogues, Melissa Molho, Heng Pan, Boris Bonaventure, Jean-Pierre Quivy, Geneviève Almouzni, Etienne Decroly, Holly Ramage, Jeffrey Johnson, Vincent Caval, Nolwenn Jouvenet

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular processes, including…

2025. ⟨hal-05409219⟩

• Article dans une revue

HIRA defines early replication initiation zones independently of their genome compartment

T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, Rocío Nunez-Vazquez, M. Marti-Renom, L. Mirny, G. Almouzni

Abstract Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the histone H3.3 chaperone…

Nature Communications, 2025, ⟨10.1038/s41467-025-65130-2⟩. ⟨hal-04790284v2⟩

• Article dans une revue

Lighting-up Transcription During Development

Yang Yu, Jinxing Ou, Nathalie Dostatni

Journal of Molecular Biology, 2025, pp.169530. ⟨10.1016/j.jmb.2025.169530⟩. ⟨hal-05382260⟩

• Article dans une revue

Insects evolved a monomeric histone-fold domain in the CENP-T protein family

Sundar Ram Sankaranarayanan, Jonathan Ulmer, Anna Mørch, Ahmad Ali-Ahmad, Nikolina Sekulić, Ines Anna Drinnenberg

Abstract The histone-fold domain (HFD) is a conserved protein interaction module that requires stabilization through a handshake interaction with an HFD partner. All HFD proteins known to date form obligate dimers to shield the extensive hydrophobic residues along the HFD. Here, we find that the…

EMBO Reports, 2025, ⟨10.1038/s44319-025-00603-5⟩. ⟨hal-05376517⟩