Verser la taxe d'apprentissage
Verser la taxe d'apprentissage
  • Santé

Dynamique du noyau | DN

  • Unité mixte de recherche

Publié le 27/04/2020 - Mis à jour le 13/12/2024

Équipes

Direction

  • Angela Taddei

Direction adjointe

  • Nathalie Dostatni

Publications sur HAL - Archive ouverte

Toutes les publications sur HAL
  • Article dans une revue

Whole genome duplication through mitotic slippage causes nuclear instability

Simon Gemble, Margot Budzyk, Anthony Simon, Ruxandra Lambuta, Luca Nanni, Nicole Weiss, Audrey Forest, Yekaterina Miroshnikova, Federica Scotto Di Carlo, Véronique Marthiens, Corentin Verdel, Jing Fang, Chantal Desdouets, Sara Wickström, Giovanni Ciriello, Elisa Oricchio, Geneviève Almouzni, Renata Basto

Abstract Whole-genome duplication (WGD), leading to polyploidy can arise in physiological and pathological contexts. WGD can occur via non-canonical cell cycles such as mitotic slippage, cytokinesis failure or endoreplication. Whether the routes to WGD influence the behaviour of the resulting…

The EMBO Journal, 2026, ⟨10.1038/s44318-026-00912-y⟩. ⟨hal-05762753⟩

  • Article dans une revue

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Maxime Chazal, Aïssatou Aïcha Sow, Elodie Le Seac'H, Dana Hawasheen, Margarida Bonifacio, Mikael Feracci, Ségolène Gracias, Adrià Sogues, Melissa Molho, Heng Pan, Boris Bonaventure, Jean-Pierre Quivy, Geneviève Almouzni, Etienne Decroly, Holly Ramage, Jeffrey R Johnson, Vincent Caval, Nolwenn Jouvenet

<div><p>Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltrans ferase, while also modulating cellular…

Journal of Virology, 2026, ⟨10.1128/jvi.00810-26⟩. ⟨hal-05717422⟩

  • Pré-publication, Document de travail

Decoding the mystery of ultra-conservation in developmental enhancers: a role for nucleosome positioning, DNA structure and transcription factor binding

Adam Woolfe, Stephen Cj Parker, Genevieve Almouzni

Abstract Many human developmental enhancers are characterized by extreme evolutionary constraint in the vertebrate lineage and unique DNA sequence properties, the functional relevance of which is still unknown. Here, we investigate the consequences of their DNA sequence features on three potential…

2026. ⟨hal-05717416⟩

  • Article dans une revue

Recent advances on mammalian DNA replication initiation and timing: From chromatin features to nuclear organization

Rocío Nunez-Vazquez, Geneviève Almouzni

<div><p>In eukaryotes, chromatin state and nuclear architecture are tightly linked to the replication timing (RT) program. Here, we consider how chromatin features operate across all scales of genome organization in mammals, from the local nucleosomal level, with histone variants and…

Current Opinion in Structural Biology, 2026, 98, pp.103274. ⟨10.1016/j.sbi.2026.103274⟩. ⟨hal-05717467⟩

Toutes les publications sur HAL

Contacts

Adresse postale

Dynamique du noyau, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
Adresse physique
Dynamique du noyau
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05 France
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