• Santé

Dynamique du noyau | DN

  • Unité mixte de recherche

Publications sur HAL - Archive ouverte

Toutes les publications sur HAL
  • Article dans une revue

Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis

Camille Landragin, Melissa Saichi, Marthe Laisné, Adeline Durand, Pacôme Prompsy, Renaud Leclere, Jérémy Mesple, Kyra Borgman, Amandine Trouchet, Marisa M Faraldo, Aurélie Chiche, Anne Vincent-Salomon, Hélène Salmon, Céline Vallot

<div><p>In breast cancer related to the BRCA1 mutation, luminal progenitor cells are believed to be the cells of origin, yet how these cells transform into invasive cancer cells remain poorly understood. Here, we combine single-cell epigenomic and transcriptomic data to reconstitute…

Molecular Cancer, 2025, 24 (1), pp.127. ⟨10.1186/s12943-025-02331-9⟩. ⟨inserm-05151042⟩

  • Article dans une revue

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

Léa Meneu, Christophe Chapard, Jacques Serizay, Alex Westbrook, Etienne Routhier, Myriam Ruault, Manon Perrot, Alexandros Minakakis, Fabien Girard, Amaury Bignaud, Antoine Even, Géraldine Gourgues, Domenico Libri, Carole Lartigue, Aurèle Piazza, Agnès Thierry, Angela Taddei, Frédéric Beckouët, Julien Mozziconacci, Romain Koszul

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in the absence of coevolution. Using bacterial genomes integrated…

Science, 2025, 387 (6734), pp.eadm9466. ⟨10.1126/science.adm9466⟩. ⟨hal-04937691⟩

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Dynamique du noyau, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
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Dynamique du noyau
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05 France
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