• Santé

Dynamique du noyau | DN

  • Unité mixte de recherche

Publié le 27/04/2020 - Mis à jour le 13/12/2024

Équipes

Direction

  • Angela Taddei

Direction adjointe

  • Nathalie Dostatni

Publications sur HAL - Archive ouverte

Toutes les publications sur HAL
  • Article dans une revue

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

Léa Meneu, Christophe Chapard, Jacques Serizay, Alex Westbrook, Etienne Routhier, Myriam Ruault, Manon Perrot, Alexandros Minakakis, Fabien Girard, Amaury Bignaud, Antoine Even, Géraldine Gourgues, Domenico Libri, Carole Lartigue, Aurèle Piazza, Agnès Thierry, Angela Taddei, Frédéric Beckouët, Julien Mozziconacci, Romain Koszul

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in the absence of coevolution. Using bacterial genomes integrated…

Science, 2025, 387 (6734), pp.eadm9466. ⟨10.1126/science.adm9466⟩. ⟨hal-04937691⟩

  • Article dans une revue

Actin-Driven Nanotopography Promotes Stable Integrin Adhesion Formation in Developing Tissue

Tianchi Chen, Cecilia Huertas Fernández-Espartero, Abigail Illand, Ching-Ting Tsai, Yang Yang, Benjamin Klapholz, Pierre Jouchet, Mélanie Fabre, Olivier Rossier, Bianxiao Cui, Sandrine Lévêque-Fort, Nicholas H Brown, Grégory Giannone

Morphogenesis requires building stable macromolecular structures from highly dynamic proteins. Muscles are anchored by long-lasting integrin adhesions to resist contractile force. However, the mechanisms governing integrin diffusion, immobilization, and activation within developing tissue remain…

Nature Communications, 2024, 15 (1), pp.8691. ⟨10.1038/s41467-024-52899-x⟩. ⟨hal-04798875⟩

  • Pré-publication, Document de travail

Single-nucleosome imaging reveals principles of transient multiscale chromatin unfolding triggered by histone ADP-ribosylation at DNA lesions

Fabiola García Fernández, Catherine Chapuis, Junwoo Park, Eva Pinto, Victor Imburchia, Edoardo José Longarini, Angela Taddei, Nataliya Sokolovska, Ivan Matić, Sébastien Huet, Judith Miné-Hattab

Timely access to DNA lesions is crucial for genome integrity. This process requires profound remodeling of densely packed chromatin to establish a repair-competent architecture. However, limited resolution has made it impossible to fully understand these remodeling events. Here, combining…

2024. ⟨hal-04782799⟩

  • Pré-publication, Document de travail

HIRA defines early replication initiation zones independently of their genome compartment

T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni

Abstract Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the histone H3.3 chaperone…

2024. ⟨hal-04790284⟩

Toutes les publications sur HAL

Contact details

Adresse postale

Dynamique du noyau, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
Adresse physique
Dynamique du noyau
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05 France
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